** PLEASE DESCRIBE THIS
IMAGE ** ** PLEASE DESCRIBE THIS
IMAGE **

Home page
General and contact information

Howard Judelson's background
education and interests

The oomycetes
learn more about these exciting organisms

The late blight disease
learn more about the problems that P. infestans causes

Research Interests
Ongoing research projects

Other lab members


Publications

Opportunities for graduate study in the lab







The response of P. infestans to fungicides

** PLEASE DESCRIBE
THIS IMAGE **
The fungicide metalaxyl used to be very effective against P. infestans worldwide. However, the emergence of resistance to this compound has led to major problems in controlling late blight.


Fungicides play a key role in controlling late blight and other oomycete diseases. Consequently, it is important to understand the basis of insensitivity to fungicides to slow the appearance of resistant strains.

This is underscored by the negative consequences of resistance developed against the systemic fungicide, metalaxyl, which wreaked havoc in the potato industry in the 1980s and 1990s. New systemic fungicides have been registered for late blight, including dimethomorph, propamocarb, and mandipropamid, however the development of resistance to these newer compounds is a threat.

Our research in this area includes studying the responses of oomycetes to fungicides, identifying genes that determine resistance, and developing rapid assays for diagnosing resistance.


** PLEASE DESCRIBE
THIS IMAGE **
High resolution melt analysis of a SNP associated with metalaxyl resistance P. infestans.


** PLEASE DESCRIBE THIS
IMAGE **
Association study of SNPs linked to metalaxyl resistance in P. infestans.


We have identified the ABC transporters from P. infestans and characterized their expression patterns in different isolates and in response to toxins. We are now studying their biochemical functions.


** toxin response **
Expression of ABC transporter superfamily of P. infestans upon exposure to different chemical and growth regimes.


Visit our publications on this and other topics here.