General and contact information
Howard Judelson's background
education and interests
learn more about these exciting organisms
The late blight disease
learn more about the problems that P. infestans causes
Ongoing research projects
Other lab members
Oomyceticides (fungicides) and P. infestans: discovery and resistance
Chemical control plays a key role in controlling late blight and other diseases caused by oomycete. It is estimated that more than 50% of the potato crop would be
lost without chemical control. Much of our lab's research has the long-term goal of identifying pathways in the pathogen that could be targets of future crop protection chemicals
(oomyceticides,commonly [but incorrectly] termed fungicides). We are also involved in projects with more short-term goals. These include studying the mechanism of action of compounds currently under development,
identifying the basis
of resistance, and designing assays to diagnose resistance within pathogen strains or populations.
We are also studying how P. infestans survives stresses imposed by chemical toxicants, including fungicides. This includes characterizing ABC transporter efflux proteins, among others.
We also partner with chemical companies and others interested in developing new oomyceticides, or studying their modes of action. This includes testing the products of high-throughput screening assays or directed strategies using dsRNA or novel formulations.