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General and contact information

Howard Judelson's background
education and interests

The oomycetes
learn more about these exciting organisms

The late blight disease
learn more about the problems that P. infestans causes

Research Interests
Ongoing research projects

Other lab members


Publications







Genomics of P. infestans, part 1


We were part of the project that used the traditional Sanger sequencing method to sequence the genome of P. infestans. Since then, we have made a major effort to improve both the genome assembly and its annotation. Using "next-generation" sequencing technologies including the Illumina and PacBio methods, we have recently generated a dramatically improved, chromosome-scale assembly. Now, we are turning our attention to a better understanding of genome evolution and genome architecture, using modern bioinformatic tools.

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Size distribution of PacBio reads

Understanding the evolution of genes is an central objective of our work. For example, illustrated below is a phylogram of the protein kinases from P. infestans. There are about 350 such proteins made by the organism, which regulate various cellular processes by regulating the phosphorylation state of a range of other enzymes, ion channels, structural proteins, and others.

The protein kinases of P. infestans.